IRF1, interferon regulatory factor 1, 3659

N. diseases: 257; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032181
Disease: Platelet Count measurement
Platelet Count measurement 		0.100 GeneticVariation phenotype GWASDB New gene functions in megakaryopoiesis and platelet formation. 22139419 2011
CUI: C0337428
Disease: Fibrinogen assay
Fibrinogen assay 		0.100 GeneticVariation phenotype GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
CUI: C1325327
Disease: fibrinogen activity
fibrinogen activity 		0.100 GeneticVariation phenotype GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
CUI: C1561955
Disease: Fibrinogen, CTCAE
Fibrinogen, CTCAE 		0.100 GeneticVariation phenotype GWASDB Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe). 20978265 2011
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 Biomarker disease GENOMICS_ENGLAND
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.380 Biomarker disease GENOMICS_ENGLAND
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.310 Biomarker disease GENOMICS_ENGLAND
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 GeneticVariation disease UNIPROT Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. 9679752 1998
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.650 GeneticVariation disease UNIPROT Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding. 10395927 1999
CUI: C0035235
Disease: Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infections 		0.210 Biomarker group RGD [Transcription factors in spinal dorsal root ganglion in rats recurrently infected with respiratory syncytial virus]. 20045913 2009
CUI: C0009766
Disease: Allergic Conjunctivitis
Allergic Conjunctivitis 		0.200 Biomarker disease RGD Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats. 14605445 2003
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.200 Biomarker group RGD Activation of type II alveolar epithelial cells during acute endotoxemia. 11880315 2002
CUI: C0029866
Disease: Other ureteric obstruction
Other ureteric obstruction 		0.200 Biomarker phenotype RGD Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction. 12787392 2003
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. 12437578 2002
CUI: C0279763
Disease: endometrial adenoacanthoma
endometrial adenoacanthoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C1153706
Disease: Endometrial adenocarcinoma
Endometrial adenocarcinoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C1336905
Disease: Endometrial Endometrioid Adenocarcinoma
Endometrial Endometrioid Adenocarcinoma 		0.200 Biomarker disease RGD Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. 19075038 2009
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.660 Biomarker disease HPO
CUI: C0007120
Disease: Bronchioloalveolar Adenocarcinoma
Bronchioloalveolar Adenocarcinoma 		0.100 Biomarker disease HPO
CUI: C0544886
Disease: Somatic mutation
Somatic mutation 		0.100 Biomarker phenotype HPO
CUI: C4703633
Disease: Increased level of L-fucose in urine
Increased level of L-fucose in urine 		0.100 Biomarker phenotype HPO
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 AlteredExpression group LHGDN Interferon regulatory factor-1 (IRF-1) mRNA expression was examined in specific cell populations (BMMC, CD34+ and CD71+) derived from 45 MDS patients and 20 controls. 16483648 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.070 GeneticVariation disease LHGDN Our findings suggest the possibility that the -300AA IRF-1 genotype is associated with outcome in patients with HCV genotype 3 infection. 16894313 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.070 GeneticVariation disease LHGDN In conclusion, our data show that genetic variants in the IRF-1 and Stat1 genes of the IFN pathway are associated with MS and HCV infection. 18338947 2008
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease LHGDN After infection by M. tuberculosis or differentiation, intact IRF-1 was recovered. 11948194 2002